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mrtf a inhibitor ccg 203971  (MedChemExpress)


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    MedChemExpress mrtf a inhibitor ccg 203971
    a Representative immunostaining images showing repressed expression of Fibronectin and F-CHP staining by SMAD3 inhibitor (SIS3) at 10 μM or MRTF-A inhibitor <t>(CCG-203971)</t> at 20 μM, individually or in combination, in TGF-β2-treated ARPE-19 cells. B Quantification of ( a ). n=3. c Experimental timeline for evaluation of dual inhibition of SMAD3 and MRTF activity in the laser-induced subretinal fibrosis model. Representative three-dimensional reconstructions images showing RPE/choroid flatmount staining for F-CHP (green), Fibronectin (red), and α-SMA (magenta) are shown, with individual channels displayed below. d Quantification of ( c ). n = 6 mice per group, with 3 laser spots per eye. Eyes with hemorrhage after laser photocoagulation were excluded from analysis. *p < 0.05; * *p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant.
    Mrtf A Inhibitor Ccg 203971, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ccg+203971/bio_rxiv__64898__2026__03__03__709397-249-13-16?v=MedChemExpress
    Average 94 stars, based on 3 article reviews
    mrtf a inhibitor ccg 203971 - by Bioz Stars, 2026-08
    94/100 stars

    Images

    1) Product Images from "Myofibroblast lineage mapping and inhibiting subretinal fibrosis by targeting SMAD3 and MRTF pathways via microRNA-24 functional study"

    Article Title: Myofibroblast lineage mapping and inhibiting subretinal fibrosis by targeting SMAD3 and MRTF pathways via microRNA-24 functional study

    Journal: bioRxiv

    doi: 10.64898/2026.03.03.709397

    a Representative immunostaining images showing repressed expression of Fibronectin and F-CHP staining by SMAD3 inhibitor (SIS3) at 10 μM or MRTF-A inhibitor (CCG-203971) at 20 μM, individually or in combination, in TGF-β2-treated ARPE-19 cells. B Quantification of ( a ). n=3. c Experimental timeline for evaluation of dual inhibition of SMAD3 and MRTF activity in the laser-induced subretinal fibrosis model. Representative three-dimensional reconstructions images showing RPE/choroid flatmount staining for F-CHP (green), Fibronectin (red), and α-SMA (magenta) are shown, with individual channels displayed below. d Quantification of ( c ). n = 6 mice per group, with 3 laser spots per eye. Eyes with hemorrhage after laser photocoagulation were excluded from analysis. *p < 0.05; * *p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant.
    Figure Legend Snippet: a Representative immunostaining images showing repressed expression of Fibronectin and F-CHP staining by SMAD3 inhibitor (SIS3) at 10 μM or MRTF-A inhibitor (CCG-203971) at 20 μM, individually or in combination, in TGF-β2-treated ARPE-19 cells. B Quantification of ( a ). n=3. c Experimental timeline for evaluation of dual inhibition of SMAD3 and MRTF activity in the laser-induced subretinal fibrosis model. Representative three-dimensional reconstructions images showing RPE/choroid flatmount staining for F-CHP (green), Fibronectin (red), and α-SMA (magenta) are shown, with individual channels displayed below. d Quantification of ( c ). n = 6 mice per group, with 3 laser spots per eye. Eyes with hemorrhage after laser photocoagulation were excluded from analysis. *p < 0.05; * *p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant.

    Techniques Used: Immunostaining, Expressing, Staining, Inhibition, Activity Assay



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    a Representative immunostaining images showing repressed expression of Fibronectin and F-CHP staining by SMAD3 inhibitor (SIS3) at 10 μM or MRTF-A inhibitor <t>(CCG-203971)</t> at 20 μM, individually or in combination, in TGF-β2-treated ARPE-19 cells. B Quantification of ( a ). n=3. c Experimental timeline for evaluation of dual inhibition of SMAD3 and MRTF activity in the laser-induced subretinal fibrosis model. Representative three-dimensional reconstructions images showing RPE/choroid flatmount staining for F-CHP (green), Fibronectin (red), and α-SMA (magenta) are shown, with individual channels displayed below. d Quantification of ( c ). n = 6 mice per group, with 3 laser spots per eye. Eyes with hemorrhage after laser photocoagulation were excluded from analysis. *p < 0.05; * *p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant.
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    a Representative immunostaining images showing repressed expression of Fibronectin and F-CHP staining by SMAD3 inhibitor (SIS3) at 10 μM or MRTF-A inhibitor <t>(CCG-203971)</t> at 20 μM, individually or in combination, in TGF-β2-treated ARPE-19 cells. B Quantification of ( a ). n=3. c Experimental timeline for evaluation of dual inhibition of SMAD3 and MRTF activity in the laser-induced subretinal fibrosis model. Representative three-dimensional reconstructions images showing RPE/choroid flatmount staining for F-CHP (green), Fibronectin (red), and α-SMA (magenta) are shown, with individual channels displayed below. d Quantification of ( c ). n = 6 mice per group, with 3 laser spots per eye. Eyes with hemorrhage after laser photocoagulation were excluded from analysis. *p < 0.05; * *p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant.
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    a Representative immunostaining images showing repressed expression of Fibronectin and F-CHP staining by SMAD3 inhibitor (SIS3) at 10 μM or MRTF-A inhibitor <t>(CCG-203971)</t> at 20 μM, individually or in combination, in TGF-β2-treated ARPE-19 cells. B Quantification of ( a ). n=3. c Experimental timeline for evaluation of dual inhibition of SMAD3 and MRTF activity in the laser-induced subretinal fibrosis model. Representative three-dimensional reconstructions images showing RPE/choroid flatmount staining for F-CHP (green), Fibronectin (red), and α-SMA (magenta) are shown, with individual channels displayed below. d Quantification of ( c ). n = 6 mice per group, with 3 laser spots per eye. Eyes with hemorrhage after laser photocoagulation were excluded from analysis. *p < 0.05; * *p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant.
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    Image Search Results


    a Representative immunostaining images showing repressed expression of Fibronectin and F-CHP staining by SMAD3 inhibitor (SIS3) at 10 μM or MRTF-A inhibitor (CCG-203971) at 20 μM, individually or in combination, in TGF-β2-treated ARPE-19 cells. B Quantification of ( a ). n=3. c Experimental timeline for evaluation of dual inhibition of SMAD3 and MRTF activity in the laser-induced subretinal fibrosis model. Representative three-dimensional reconstructions images showing RPE/choroid flatmount staining for F-CHP (green), Fibronectin (red), and α-SMA (magenta) are shown, with individual channels displayed below. d Quantification of ( c ). n = 6 mice per group, with 3 laser spots per eye. Eyes with hemorrhage after laser photocoagulation were excluded from analysis. *p < 0.05; * *p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant.

    Journal: bioRxiv

    Article Title: Myofibroblast lineage mapping and inhibiting subretinal fibrosis by targeting SMAD3 and MRTF pathways via microRNA-24 functional study

    doi: 10.64898/2026.03.03.709397

    Figure Lengend Snippet: a Representative immunostaining images showing repressed expression of Fibronectin and F-CHP staining by SMAD3 inhibitor (SIS3) at 10 μM or MRTF-A inhibitor (CCG-203971) at 20 μM, individually or in combination, in TGF-β2-treated ARPE-19 cells. B Quantification of ( a ). n=3. c Experimental timeline for evaluation of dual inhibition of SMAD3 and MRTF activity in the laser-induced subretinal fibrosis model. Representative three-dimensional reconstructions images showing RPE/choroid flatmount staining for F-CHP (green), Fibronectin (red), and α-SMA (magenta) are shown, with individual channels displayed below. d Quantification of ( c ). n = 6 mice per group, with 3 laser spots per eye. Eyes with hemorrhage after laser photocoagulation were excluded from analysis. *p < 0.05; * *p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant.

    Article Snippet: Beginning 7 days after laser photocoagulation, mice received daily intraperitoneal injections of the MRTF-A inhibitor CCG-203971 (MedChemExpress, HY-108361)(100 mg/kg), the SMAD3 inhibitor SIS3 (Sigma, S0447) (2.5 mg/kg), or a combination of both compounds for an additional 2 weeks.

    Techniques: Immunostaining, Expressing, Staining, Inhibition, Activity Assay

    a Representative immunostaining images showing repressed expression of Fibronectin and F-CHP staining by SMAD3 inhibitor (SIS3) at 10 μM or MRTF-A inhibitor (CCG-203971) at 20 μM, individually or in combination, in TGF-β2-treated ARPE-19 cells. B Quantification of ( a ). n=3. c Experimental timeline for evaluation of dual inhibition of SMAD3 and MRTF activity in the laser-induced subretinal fibrosis model. Representative three-dimensional reconstructions images showing RPE/choroid flatmount staining for F-CHP (green), Fibronectin (red), and α-SMA (magenta) are shown, with individual channels displayed below. d Quantification of ( c ). n = 6 mice per group, with 3 laser spots per eye. Eyes with hemorrhage after laser photocoagulation were excluded from analysis. *p < 0.05; * *p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant.

    Journal: bioRxiv

    Article Title: Myofibroblast lineage mapping and inhibiting subretinal fibrosis by targeting SMAD3 and MRTF pathways via microRNA-24 functional study

    doi: 10.64898/2026.03.03.709397

    Figure Lengend Snippet: a Representative immunostaining images showing repressed expression of Fibronectin and F-CHP staining by SMAD3 inhibitor (SIS3) at 10 μM or MRTF-A inhibitor (CCG-203971) at 20 μM, individually or in combination, in TGF-β2-treated ARPE-19 cells. B Quantification of ( a ). n=3. c Experimental timeline for evaluation of dual inhibition of SMAD3 and MRTF activity in the laser-induced subretinal fibrosis model. Representative three-dimensional reconstructions images showing RPE/choroid flatmount staining for F-CHP (green), Fibronectin (red), and α-SMA (magenta) are shown, with individual channels displayed below. d Quantification of ( c ). n = 6 mice per group, with 3 laser spots per eye. Eyes with hemorrhage after laser photocoagulation were excluded from analysis. *p < 0.05; * *p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant.

    Article Snippet: CCG-203971 (MedChemExpress, HY-108361) is a MTRF inhibitor functioning by blocking MRTF nuclear accumulation.

    Techniques: Immunostaining, Expressing, Staining, Inhibition, Activity Assay

    Journal: Advanced Science

    Article Title: Pirin Inhibits FAS‐Mediated Apoptosis to Support Colorectal Cancer Survival

    doi: 10.1002/advs.202301476

    Figure Lengend Snippet:

    Article Snippet: CCG‐203971 , Selleck Chemicals , S8469.

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